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In 1926, Newt Scamander arrives at the Magical Congress of the United States of America with a magically expanded briefcase, which houses a number of dangerous creatures and their habitats. When the creatures escape from the briefcase, it sends the American wizarding authorities after Newt, and threatens to strain even further the state of magical and non-magical relations.
Rose, a rebellious half-vampire/half-human guardian-in-training and her best friend, Lissa -- a mortal, royal vampire Princess - have been on the run when they are captured and returned to St. Vladamirs Academy, the very place where they believe their lives may be in most jeopardy. Rose will sacrifice everything to protect Lissa from those who intend to exploit her from within the Academy walls and the Strigoi (immortal, evil vampires) who hunt her kind from outside its sanctuary.