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I 'Anja og Viktor – I medgang og modgang', den femte Anja og Viktor-film, er parret kommet i pengemangel. De bor sammen med deres lille datter i vennernes ramponerede øvelokale i Sydhavnen, men da kommunens ivrige mand afslører dem i at bruge øvelokalet som bolig, og de nu regulært står på gaden, hvis de ikke skaffer penge til lejligheden, er familien i en presset situation.
Egon escapes from the psychiatric ward, where he has been incarcerated since the gang's last coup. Keld and Benny pick him up, and when Egon, as always, is planning the big heist, the Olsen Gang is once again on the move.
As usual, Egon has an ingenious plan. And, as usual, it works just fine until one of the gang members makes some kind of funny error. This time, however, even Egon's life is in danger, for some international criminals try to get rid of him by throwing him into a container filled with acid.